WebDapL catalyzes the conversion of tetrahydrodipicolinate (THDPA) to L,L-diaminopimelate (L,L-DAP), in one step bypassing the DapD, DapC and DapE enzymatic reactions present in … Web26 Sep 2014 · The first step characterized by the synthesis of tetrahydrodipicolinate acid (THDP) from aspartate (asp) is a general feature of all four variants. This conversion is carried out in a series of reactions by the enzymes; LysC (EC: 2.7.2.4), asd (EC: 1.2.1.11), DapA (EC: 4.2.1.52), and DapB (EC: 1.2.1.26) (Figure 1A ).
Frontiers L,L-diaminopimelate aminotransferase (DapL): a putative …
WebThe four variants share the common steps of converting L-aspartate to THDPA by aspartokinase (AK, EC:2.7.2.4), as- partic semialdehyde dehydrogenase (AsaDH, EC:1.2.1.11), dihydrodipicolinate synthetase (DHDPS, EC:4.3.3.7), and dihydrodipicolinate reductase (DHDPR, EC:1.17.1.8) in turn. Web7 Sep 2024 · First, we confirmed that strain AGMB03513 T has the lysC, asd, dapA, and dapB genes required for conversion from l -aspartate to THDPA. Next, there are several pathways that convert THDPA to meso -DAP (Xu et al. 2024 ), among which the isolate has the dapDH gene that is involved in the succinylase pathway. infant feeding table
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WebIn addition to the natural substrate, THDPA, one cyclic and several acyclic compounds are also succinylated. 2-Hydroxytetrahydropyran-2,6-dicarboxylic acid is a potent competitive … WebTHDPA Succinylase Assay-The assay for THDPA succinylase is based on the different binding affinities of THDPA and N-succinyl- 2-amino-6-keto-~-pimelic acid for a cation … WebThese pathways share the steps converting L-aspartate to L-2,3,4,5- tetrahydrodipicolinate (THDPA), but the subsequent steps leading to the production of meso-diaminopimelate, the immediate precursor of L-lysine, are different [].The succinylase pathway acylates THDPA with succinyl-CoA to generate N-succinyl-LL-2-amino-6-ketopimelate and forms meso … infant feeding table seats