Irf8 genecards
WebInterferon regulatory factor (IRF)-8 is a critical transcription factor involved in the pathogenesis of myeloid neoplasia. However, the underlying mechanisms in vivo are not well known. In myeloid cells, IRF8 regulates the expression of Bax and Fas to regulate apoptosis. In chronic myelogenous leukemia (CML), IRF8 regulates acid ceramidase to mediate CML apoptosis. IRF8 is highly expressed in myeloid cells and was originally identified in as a critical lineage-specific transcription factor for myeloid cell differentiation, recent studies, however, have shown that IRF8 is also constitutively expressed in non-hematopoietic cancer cells, albeit at a lower leve…
Irf8 genecards
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WebIRF8 is a Reliable Monoblast Marker for Acute Monocytic Leukemias. PU.1 and IRF8 Modulate Activation of NLRP3 Inflammasome via Regulating Its Expression in Human … WebNov 15, 2008 · IRF8 is known to bind to any of 4 distinct target sequences in genes subject to transcriptional activation or repression by IRF8. 29 Studies of the regulatory sequences of Sfpi1, which encodes PU.1, identified 2 possible IRF8 target sites.
WebIFN regulatory factor (IRF) 8 is a transcription factor that has a key role in the cellular response to IFN-γ and is pivotal in myeloid cell differentiation. Whether IRF8 plays a role in the development and function of microglia, the tissue-resident myeloid cells of … WebMar 21, 2024 · IRF8 is a transcriptional activator of CD37 expression in diffuse large B-cell lymphoma. Global assessment of IRF8 as a novel cancer biomarker. Predicting the …
WebOct 4, 2024 · IRF8, or ICSBP, is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. The family also includes IRF1 ( 147575 ), IRF2 ( 147576 ), and ISGF3 (see … Web(Click on the icon in the table below to see search hit context)
WebProtein Interferon regulatory factor 8 Gene Irf8 Status UniProtKB reviewed (Swiss-Prot) Organism Mus musculus (Mouse) Amino acids 424 Protein existence Evidence at protein level Annotation score 5/5 Entry Feature viewer Publications External links History BLAST Download Add a publication Entry feedback Function
media state authentication failedWebGeneCards Team; Log In / Sign Up; My Genes; Showing 25 of 1,697 results for acap1 Search Time: 0 ms in NEW (Click on the icon in the table below to see search hit context) Showing of 1,697 Results for acap1 Search Time: 0 ms. Export Show: Symbol Description Category UniProt ID GIFtS GC id Score ... pendleton golf head coversWebIRF8: Interferon Regulatory Factor 8: Protein Coding: Q02556: 52: GC16P085898: 104.12: 2: FOXF1: Forkhead Box F1: Protein Coding: Q12946: 48: GC16P086510: 13.39: 3: … media staffing solutionsWebSep 20, 2016 · Interferon regulatory factor-8 (IRF8) has been proposed to be essential for development of monocytes, plasmacytoid dendritic cells (pDCs) and type 1 conventional … pendleton grand canyon throwWebApr 14, 2024 · Edward Miller. Edward Michael Miller, 85, of Riley Township, passed away at his home on Tuesday, April 3, 2024. He was born in Detroit, February 15, 1938, the son of … media sportshdWebIRF8 expression based on TCGA samples Transcript per million Expression of IRF8 in LUAD based on Sample types Normal (n=59) Primary tumor (n=515) 0 10 20 30 40 50 60 LUAD : Lung adenocarcinoma Pan-cancer view Methylation Survival Protein Exp (CPTAC) Correlated genes DepMap External Links media staffing companyWebFeb 15, 2008 · IRF8 binds to certain DNA motifs such as ISRE and Ets/IRF composite elements by interacting with partner proteins that include IRF members and Ets family proteins. 12, 15 Although IRF8 can regulate gene expression through other mechanisms, the interaction with partners is thought to be a critical requirement for macrophage … pendleton gun show