WebNov 13, 2024 · We found that ~5% of bone marrow F4/80+ macrophages and ~35% of fetal liver F4/80+ macrophages express Epor-GFP. As negative control, no Epor-GFP macrophages are noted in wild type F4/80+ macrophages. WebNov 18, 2024 · Functional EpoR is expressed in subsets of tissue macrophages and hematopoietic cells. EpoR-tdTomato-Cre mouse line provides a powerful tool for identification of EpoR expression and gene manipulation in EpoR-expressing cells. Sign In - EpoR-tdTomato-Cre mice enable identification of EpoR expression in ...
A subpopulation of mouse lung tissue-resident macrophages …
WebAug 18, 2024 · Background: Tissue-resident macrophages can be educated to tumor-associated macrophages (TAMs) by the tumor microenvironment and many types of macrophages express erythropoietic receptor (EPOR); However, little is known about the expression of EPOR on TAMs and the identity of EPOR + TAMs in osteosarcoma lung … WebActivated erythropoietin (EPO) receptor (EPOR) signaling causes erythrocytosis. The important role of macrophages for the erythroid expansion and differentiation process has been reported, both in baseline and stress erythropoiesis. However, the significance of EPOR signaling for regulation of macrophages contributing to erythropoiesis has not … arkansas dsw
Identification and Functional Analysis of EPOR+ Tumor-Associated ...
WebTAMs expressing EPOR and CD163+EPOR+ macrophages as TAMs in osteosarcoma lung metastasis patients, which are highly associated with tumor aggressiveness are characterized. Background Tissue-resident macrophages can be educated to tumor-associated macrophages (TAMs) by the tumor microenvironment and many types of … WebNov 18, 2024 · Notably, accumulating evidence suggests that EpoR is expressed well beyond erythroid cells. However, the expression of EpoR in non-erythroid cells has been … WebThe identity of EBI macrophages has thus far remained elusive. Given that Epo is essential for erythropoiesis and that Epor is expressed in numerous nonerythroid cells, we hypothesized that EBI macrophages express Epor so that Epo can act on both erythroid cells and EBI macrophages simultaneously to ensure efficient erythropoiesis. bali sun news