WebJan 1, 2010 · Since the chromosome abnormalities are related to cytokinesis failure and cell death during mitosis (Normand and King, 2010), the cell mitotic catastrophe may not only result from the inhibition ... WebSep 17, 2015 · Cytokinesis failure caused by RhoA deficiency resulted in p53 activation and p21-transcriptional upregulation with associated cell-cycle arrest, increased DNA damage, and cell death. Our findings demonstrate the role of RhoA as a critical regulator for efficient erythroblast proliferation and the p53 pathway as a powerful quality control ...
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WebNational Center for Biotechnology Information WebFeb 14, 2024 · Abstract. Mutations in citron (CIT), leading to loss or inactivation of the citron kinase protein (CITK), cause primary microcephaly in humans and rodents, associated with cytokinesis failure and apoptosis in neural progenitors. We show that CITK loss induces DNA damage accumulation and chromosomal instability in both mammals and Drosophila. blackberry sth100-1 firmware
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WebApr 12, 2024 · Time-lapse analysis of v-Src-expressing cells showed that cytokinesis failure is caused by cleavage furrow regression. Microscopic analysis revealed that v-Src induces delocalization of cytokinesis regulators including Aurora B and Mklp1. Tetraploid cell formation is one of the causes of chromosome instability; however, tetraploid cells … Webfailure (n.). 1640年代, failer ,意为“失败,缺陷”,也指“失败的行为”,源自盎格鲁-法语词汇 failer ,古法语 falir ,意为“缺乏;未成功”(参见fail(v.))。 在盎格鲁-法语中,动词被用作名词;17世纪英语将其结尾改为与-ure中的单词相一致。 指“被视为失败的事物或人”的含义始 … WebCytokinesis defects and cancer. Whole-genome and centrosome duplication as a consequence of cytokinesis failure can drive tumorigenesis in experimental model … blackberry stems cleansing houses